A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Accumulating evidence indicates that purinergic P2X4 receptors (P2X4R: cation channels activated by extracellular ATP) expressed in spinal microglia are crucial for pathological chronic pain caused by nerve damage, suggesting a potential target for drug discovery. We identified NP-1815-PX (5-[3-(5-t...

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Detalles Bibliográficos
Autores principales: Matsumura, Yuta, Yamashita, Tomohiro, Sasaki, Atsushi, Nakata, Eriko, Kohno, Keita, Masuda, Takahiro, Tozaki-Saitoh, Hidetoshi, Imai, Toshiyasu, Kuraishi, Yasushi, Tsuda, Makoto, Inoue, Kazuhide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006034/
https://www.ncbi.nlm.nih.gov/pubmed/27576299
http://dx.doi.org/10.1038/srep32461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006034/
https://www.ncbi.nlm.nih.gov/pubmed/27576299
http://dx.doi.org/10.1038/srep32461

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