Biosimilar structural comparability assessment by NMR: from small proteins to monoclonal antibodies

Biosimilar drug products must have a demonstrated similarity with respect to the reference product’s molecules in order to ensure both the effectiveness of the drug and the patients’ safety. In this paper the fusion framework of a highly sensitive NMR fingerprinting approach for conformational chang...

Descripción completa

Detalles Bibliográficos
Autores principales: Japelj, Boštjan, Ilc, Gregor, Marušič, Jaka, Senčar, Jure, Kuzman, Drago, Plavec, Janez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006049/
https://www.ncbi.nlm.nih.gov/pubmed/27578487
http://dx.doi.org/10.1038/srep32201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006049/
https://www.ncbi.nlm.nih.gov/pubmed/27578487
http://dx.doi.org/10.1038/srep32201

Ejemplares similares