Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

Activation of telomerase or alternative lengthening of telomeres (ALT) is necessary for tumours to escape from dysfunctional telomere-mediated senescence. Anti-telomerase drugs might be effective in suppressing tumour growth in approximately 85–90% of telomerase-positive cancer cells. However, there...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Yang, Shi, Guang, Zhang, Laichen, Li, Feng, Jiang, Yuanling, Jiang, Shuai, Ma, Wenbin, Zhao, Yong, Songyang, Zhou, Huang, Junjiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006076/
https://www.ncbi.nlm.nih.gov/pubmed/27578458
http://dx.doi.org/10.1038/srep32280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006076/
https://www.ncbi.nlm.nih.gov/pubmed/27578458
http://dx.doi.org/10.1038/srep32280

Ejemplares similares