Cargando…

Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo

The vast majority of chronic and recurrent bacterial diseases are attributed to the presence of a recalcitrant biofilm that contributes significantly to pathogenesis. As such, these diseases will require an innovative therapeutic approach. We targeted DNABII proteins, an integral component of extrac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Novotny, Laura A., Jurcisek, Joseph A., Goodman, Steven D., Bakaletz, Lauren O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006588/ https://www.ncbi.nlm.nih.gov/pubmed/27342872 http://dx.doi.org/10.1016/j.ebiom.2016.06.022

Ejemplares similares

Monoclonal antibodies that target extracellular DNABII proteins or the type IV pilus of nontypeable Haemophilus influenzae (NTHI) worked additively to disrupt 2-genera biofilms
por: Jurcisek, Joseph A., et al.
Publicado: (2022)

Targeting a bacterial DNABII protein with a chimeric peptide immunogen or humanised monoclonal antibody to prevent or treat recalcitrant biofilm-mediated infections
por: Novotny, Laura A., et al.
Publicado: (2020)

Redirecting the immune response towards immunoprotective domains of a DNABII protein resolves experimental otitis media
por: Novotny, L. A., et al.
Publicado: (2019)

The DNABII family of proteins is comprised of the only nucleoid associated proteins required for nontypeable Haemophilus influenzae biofilm structure
por: Devaraj, Aishwarya, et al.
Publicado: (2017)

DNABII targeting antibodies as vaccines against biofilm diseases
por: D'Andrea, Marco M., et al.
Publicado: (2020)

Nontypeable Haemophilus influenzae newly released (NRel) from biofilms by antibody-mediated dispersal versus antibody-mediated disruption are phenotypically distinct
por: Mokrzan, Elaine M., et al.
Publicado: (2020)

Structural Stability of Burkholderia cenocepacia Biofilms Is Reliant on eDNA Structure and Presence of a Bacterial Nucleic Acid Binding Protein
por: Novotny, Laura A., et al.
Publicado: (2013)

Bacterial Biofilms Utilize an Underlying Extracellular DNA Matrix Structure That Can Be Targeted for Biofilm Resolution
por: Goodman, Steven D., et al.
Publicado: (2022)

In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo
por: Brown, Jonathan R., et al.
Publicado: (2019)

In vitro Biofilm Formation in an 8-well Chamber Slide
por: Jurcisek, Joseph A., et al.
Publicado: (2011)

Crumbling the Castle: Targeting DNABII Proteins for Collapsing Bacterial Biofilms as a Therapeutic Approach to Treat Disease and Combat Antimicrobial Resistance
por: Rogers, James V., et al.
Publicado: (2022)

Nontypeable Haemophilus influenzae released from biofilm residence by monoclonal antibody directed against a biofilm matrix component display a vulnerable phenotype
por: Wilbanks, Kathryn Q., et al.
Publicado: (2023)

ESKAPEE pathogens newly released from biofilm residence by a targeted monoclonal are sensitized to killing by traditional antibiotics
por: Kurbatfinski, Nikola, et al.
Publicado: (2023)

Immunization with a Biofilm-Disrupting Nontypeable Haemophilus influenzae Vaccine Antigen Did Not Alter the Gut Microbiome in Chinchillas, Unlike Oral Delivery of a Broad-Spectrum Antibiotic Commonly Used for Otitis Media
por: Bailey, Michael T., et al.
Publicado: (2020)

Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae
por: Das, Jayajit, et al.
Publicado: (2017)

The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media
por: Blakeway, Luke V., et al.
Publicado: (2019)

Antibodies against the Majority Subunit (PilA) of the Type IV Pilus of Nontypeable Haemophilus influenzae Disperse Moraxella catarrhalis from a Dual-Species Biofilm
por: Mokrzan, Elaine M., et al.
Publicado: (2018)

Respiratory Syncytial Virus Promotes Moraxella catarrhalis-Induced Ascending Experimental Otitis Media
por: Brockson, M. Elizabeth, et al.
Publicado: (2012)

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
por: Dobson, Claire L., et al.
Publicado: (2016)

Editorial: Women in biofilms 2021
por: Almeida, Carina, et al.
Publicado: (2022)

Monoclonal Antibody Disrupts Biofilm Structure and Restores Antibiotic Susceptibility in an Orthopedic Implant Infection Model
por: Burke, Zachary D. C., et al.
Publicado: (2023)

Introduction and clearance of beta‐glucan in the downstream processing of monoclonal antibodies
por: Kluters, Simon, et al.
Publicado: (2021)

Enhanced Probiotic Potential of Lactobacillus reuteri When Delivered as a Biofilm on Dextranomer Microspheres That Contain Beneficial Cargo
por: Navarro, Jason B., et al.
Publicado: (2017)

1640. Toward New Anti-Biofilm Therapies: High Mobility Group Box 1 (HMGB1) Protein and Its Structural Variants Can Be Used to Disrupt Bacterial Biofilms (BBs)
por: Katragkou, Aspasia, et al.
Publicado: (2018)

Plasma clearance of an antibody--enzyme conjugate in ADEPT by monoclonal anti-enzyme: its effect on prodrug activation in vivo.
por: Rogers, G. T., et al.
Publicado: (1995)

Poly (acetyl, arginyl) glucosamine disrupts Pseudomonas aeruginosa biofilms and enhances bacterial clearance in a rat lung infection model
por: Garcia, Bryan A., et al.
Publicado: (2022)

Viral–bacterial co-infections in the respiratory tract
por: Bakaletz, Lauren O
Publicado: (2017)

Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm
por: de Vor, Lisanne, et al.
Publicado: (2022)

Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli
por: Tursi, Sarah A., et al.
Publicado: (2020)

Monoclonal Antibody against G Glycoprotein Increases Respiratory Syncytial Virus Clearance In Vivo and Prevents Vaccine-Enhanced Diseases
por: Lee, Hyo-Jeong, et al.
Publicado: (2017)

Prediction of Clearance of Monoclonal and Polyclonal Antibodies and Non-Antibody Proteins in Children: Application of Allometric Scaling
por: Mahmood, Iftekhar
Publicado: (2020)

Blockade of clearance of immune complexes by an anti-F(cγ) receptor monoclonal antibody
por: Clarkson, SB, et al.
Publicado: (1986)

A Novel Approach to Monitor Clearance of Host Cell Proteins Associated With Monoclonal Antibodies
por: Aboulaich, Nabila, et al.
Publicado: (2014)

Monoclonal Antibodies to Disrupt Progression of Early Covid-19 Infection
por: Cohen, Myron S.
Publicado: (2021)

Production of Monoclonal Antibodies Specific to FimA of Porphyromonas gingivalis and Their Inhibitory Activity on Bacterial Binding
por: Koh, Eun-Mi, et al.
Publicado: (2009)

Mixing Performance of the Modified Tesla Micromixer with Tip Clearance
por: Juraeva, Makhsuda, et al.
Publicado: (2022)

Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages
por: Abu Khweek, Arwa, et al.
Publicado: (2013)

An Optical Fiber Bundle Sensor for Tip Clearance and Tip Timing Measurements in a Turbine Rig
por: García, Iker, et al.
Publicado: (2013)

A Blade Defect Diagnosis Method by Fusing Blade Tip Timing and Tip Clearance Information
por: Zhang, Ji-wang, et al.
Publicado: (2018)

Anti-tax interacting protein-1 (TIP-1) monoclonal antibody targets human cancers
por: Yan, Heping, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_r6pj9qcs2kbmaeoal43ehkp65o