Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis

BACKGROUND: Visceral leishmaniasis (VL) caused by the protozoan parasite Leishmania donovani causes severe disease. Age appears to be critical in determining the clinical outcome of VL and at present there is no effective vaccine available against VL for any age group. Previously, we showed that gen...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Parna, Dey, Ranadhir, Dagur, Pradeep K., Joshi, Amritanshu B., Ismail, Nevien, Gannavaram, Sreenivas, Debrabant, Alain, Akue, Adovi D., KuKuruga, Mark A., Selvapandiyan, Angamuthu, McCoy, John Philip, Nakhasi, Hira L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007048/
https://www.ncbi.nlm.nih.gov/pubmed/27580076
http://dx.doi.org/10.1371/journal.pntd.0004963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007048/
https://www.ncbi.nlm.nih.gov/pubmed/27580076
http://dx.doi.org/10.1371/journal.pntd.0004963

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