Cargando…

Ribosomal proteins produced in excess are degraded by the ubiquitin–proteasome system

Ribosome assembly is an essential process that consumes prodigious quantities of cellular resources. Ribosomal proteins cannot be overproduced in Saccharomyces cerevisiae because the excess proteins are rapidly degraded. However, the responsible quality control (QC) mechanisms remain poorly characte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sung, Min-Kyung, Reitsma, Justin M., Sweredoski, Michael J., Hess, Sonja, Deshaies, Raymond J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007085/ https://www.ncbi.nlm.nih.gov/pubmed/27385339 http://dx.doi.org/10.1091/mbc.E16-05-0290

Ejemplares similares

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins
por: Sung, Min-Kyung, et al.
Publicado: (2016)

Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System
por: Chou, Tsui-Fen, et al.
Publicado: (2011)

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
por: Deshaies, Raymond J
Publicado: (2014)

Perturbations to the Ubiquitin Conjugate Proteome in Yeast Δubx Mutants Identify Ubx2 as a Regulator of Membrane Lipid Composition
por: Kolawa, Natalie, et al.
Publicado: (2013)

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
por: Chan, Nickie C., et al.
Publicado: (2011)

The Steady-State Repertoire of Human SCF Ubiquitin Ligase Complexes Does Not Require Ongoing Nedd8 Conjugation
por: Lee, J. Eugene, et al.
Publicado: (2011)

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle
por: Mosadeghi, Ruzbeh, et al.
Publicado: (2016)

Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins
por: Goh, Amanda M, et al.
Publicado: (2008)

How the 26S Proteasome Degrades Ubiquitinated Proteins in the Cell
por: Coll-Martínez, Bernat, et al.
Publicado: (2019)

Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis
por: Xiong, Yi, et al.
Publicado: (2022)

Eukaryotic Cells Producing Ribosomes Deficient in Rpl1 Are Hypersensitive to Defects in the Ubiquitin-Proteasome System
por: McIntosh, Kerri B., et al.
Publicado: (2011)

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
por: Gu, Xin, et al.
Publicado: (2023)

Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins
por: Abi Habib, Joanna, et al.
Publicado: (2020)

The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy
por: Zientara-Rytter, Katarzyna, et al.
Publicado: (2019)

Proteins Directly Interacting with Mammalian 20S Proteasomal Subunits and Ubiquitin-Independent Proteasomal Degradation
por: Sánchez-Lanzas, Raúl, et al.
Publicado: (2014)

F-box Protein FBXL16 Binds PP2A-B55α and Regulates Differentiation of Embryonic Stem Cells along the FLK1+ Lineage
por: Honarpour, Narimon, et al.
Publicado: (2014)

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome
por: Verma, Rati, et al.
Publicado: (2013)

Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway
por: Collins, Ian, et al.
Publicado: (2017)

Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins
por: Nathan, James A., et al.
Publicado: (2013)

Vms1/Ankzf1 peptidyl-tRNA hydrolase releases nascent chains from stalled ribosomes
por: Verma, Rati, et al.
Publicado: (2018)

Regulating the 20S Proteasome Ubiquitin-Independent Degradation Pathway
por: Ben-Nissan, Gili, et al.
Publicado: (2014)

The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine Disease
por: Nath, Samir R., et al.
Publicado: (2017)

Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation
por: Tsuchiya, Hikaru, et al.
Publicado: (2020)

Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System
por: Abbas, Ruqaia, et al.
Publicado: (2021)

The recognition of ubiquitinated proteins by the proteasome
por: Grice, Guinevere L., et al.
Publicado: (2016)

Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation
por: Choi, Won Hoon, et al.
Publicado: (2016)

Protein degradation by ubiquitin–proteasome system in formation and labilization of contextual conditioning memory
por: Sol Fustiñana, María, et al.
Publicado: (2014)

Ubiquitin-independent proteasomal degradation driven by C-degron pathways
por: Makaros, Yaara, et al.
Publicado: (2023)

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation
por: Lindsten, Kristina, et al.
Publicado: (2002)

Ubiquitin modulates 26S proteasome conformational dynamics and promotes substrate degradation
por: Jonsson, Erik, et al.
Publicado: (2022)

Hepatitis C virus core protein activates proteasomal activator 28 gamma to downregulate p16 levels via ubiquitin-independent proteasomal degradation
por: Cha, Sungkyung, et al.
Publicado: (2021)

Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast
por: Maurer, Matthew J., et al.
Publicado: (2016)

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates
por: Korolchuk, Viktor I., et al.
Publicado: (2009)

Ubiquitin-mediated proteasome degradation regulates optic fissure fusion
por: Pereira Piedade, Warlen, et al.
Publicado: (2019)

The yeast mitophagy receptor Atg32 is ubiquitinated and degraded by the proteasome
por: Camougrand, Nadine, et al.
Publicado: (2020)

Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy
por: Sun, Xiao-Xin, et al.
Publicado: (2021)

Ubiquitin-Dependent and Independent Proteasomal Degradation in Host-Pathogen Interactions
por: Bialek, Wojciech, et al.
Publicado: (2023)

Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1
por: Gomez, Tara A, et al.
Publicado: (2011)

Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system
por: Guharoy, Mainak, et al.
Publicado: (2016)

Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway
por: Liu, Pinduo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mn915gngadfbchfv95r8b64aos