Molecular and cellular effects of a novel hydroxamate-based HDAC inhibitor – belinostat – in glioblastoma cell lines: a preliminary report

Histone deacetylase (HDAC) inhibitors are now intensively investigated as potential cytostatic agents in many malignancies. Here, we provide novel information concerning the influence of belinostat (Bel), a hydroxamate-based pan-HDAC inhibitor, on glioblastoma LN-229 and LN-18 cells. We found that L...

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Detalles Bibliográficos
Autores principales: Kusaczuk, Magdalena, Krętowski, Rafał, Stypułkowska, Anna, Cechowska-Pasko, Marzanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007275/
https://www.ncbi.nlm.nih.gov/pubmed/27468826
http://dx.doi.org/10.1007/s10637-016-0372-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007275/
https://www.ncbi.nlm.nih.gov/pubmed/27468826
http://dx.doi.org/10.1007/s10637-016-0372-5

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