YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

BACKGROUND & AIMS: Pancreatitis is the most important risk factor for pancreatic ductal adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process of acinar cell reprogramming known as acinar-to-ductal metaplasia (ADM)—a precursor of pancreatic intraepithelial neoplasia...

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Detalles Bibliográficos
Autores principales: Gruber, Ralph, Panayiotou, Richard, Nye, Emma, Spencer-Dene, Bradley, Stamp, Gordon, Behrens, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007286/
https://www.ncbi.nlm.nih.gov/pubmed/27215660
http://dx.doi.org/10.1053/j.gastro.2016.05.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007286/
https://www.ncbi.nlm.nih.gov/pubmed/27215660
http://dx.doi.org/10.1053/j.gastro.2016.05.006

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