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Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution

The normal distribution of nuclear envelope transmembrane proteins (NETs) is disrupted in several human diseases. NETs are synthesized on the endoplasmic reticulum and then transported from the outer nuclear membrane (ONM) to the inner nuclear membrane (INM). Quantitative determination of the distri...

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Detalles Bibliográficos
Autores principales: Mudumbi, Krishna C, Schirmer, Eric C, Yang, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007294/
https://www.ncbi.nlm.nih.gov/pubmed/27558844
http://dx.doi.org/10.1038/ncomms12562