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Targeting of Fzr/Cdh1 for timely activation of the APC/C at the centrosome during mitotic exit

A multi-subunit ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C), regulates critical cellular processes including the cell cycle. To accomplish its diverse functions, APC/C activity must be precisely regulated in time and space. The interphase APC/C activator Fizzy-related (Fzr or...

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Detalles Bibliográficos
Autores principales: Meghini, Francesco, Martins, Torcato, Tait, Xavier, Fujimitsu, Kazuyuki, Yamano, Hiroyuki, Glover, David M., Kimata, Yuu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007356/
https://www.ncbi.nlm.nih.gov/pubmed/27558644
http://dx.doi.org/10.1038/ncomms12607