Hypersensitivity to DNA damage in antephase as a safeguard for genome stability

Activation of the DNA-damage response can lead to the induction of an arrest at various stages in the cell cycle. These arrests are reversible in nature, unless the damage is too excessive. Here we find that checkpoint reversibility is lost in cells that are in very late G2, but not yet fully commit...

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Detalles Bibliográficos
Autores principales: Feringa, Femke M., Krenning, Lenno, Koch, André, van den Berg, Jeroen, van den Broek, Bram, Jalink, Kees, Medema, René H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007458/
https://www.ncbi.nlm.nih.gov/pubmed/27561326
http://dx.doi.org/10.1038/ncomms12618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007458/
https://www.ncbi.nlm.nih.gov/pubmed/27561326
http://dx.doi.org/10.1038/ncomms12618

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