Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer’s disease

The oligomeric amyloid-β (Aβ) peptide is thought to contribute to the subtle amnesic changes in Alzheimer’s disease (AD) by causing synaptic dysfunction. Here, we examined the time course of synaptic changes in mouse hippocampal neurons following exposure to Aβ(42) at picomolar concentrations, mimic...

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Detalles Bibliográficos
Autores principales: Koppensteiner, Peter, Trinchese, Fabrizio, Fà, Mauro, Puzzo, Daniela, Gulisano, Walter, Yan, Shijun, Poussin, Arthur, Liu, Shumin, Orozco, Ian, Dale, Elena, Teich, Andrew F., Palmeri, Agostino, Ninan, Ipe, Boehm, Stefan, Arancio, Ottavio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007504/
https://www.ncbi.nlm.nih.gov/pubmed/27581852
http://dx.doi.org/10.1038/srep32553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007504/
https://www.ncbi.nlm.nih.gov/pubmed/27581852
http://dx.doi.org/10.1038/srep32553

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