Negatively charged residues of the segment linking the enzyme and cytolysin moieties restrict the membrane-permeabilizing capacity of adenylate cyclase toxin

The whooping cough agent, Bordetella pertussis, secretes an adenylate cyclase toxin-hemolysin (CyaA) that plays a crucial role in host respiratory tract colonization. CyaA targets CR3-expressing cells and disrupts their bactericidal functions by delivering into their cytosol an adenylate cyclase enz...

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Detalles Bibliográficos
Autores principales: Masin, Jiri, Osickova, Adriana, Sukova, Anna, Fiser, Radovan, Halada, Petr, Bumba, Ladislav, Linhartova, Irena, Osicka, Radim, Sebo, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007505/
https://www.ncbi.nlm.nih.gov/pubmed/27581058
http://dx.doi.org/10.1038/srep29137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007505/
https://www.ncbi.nlm.nih.gov/pubmed/27581058
http://dx.doi.org/10.1038/srep29137

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