Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways

Liraglutide, a glucagon-like peptide-1 receptor (GLP-1R) agonist, is widely used to treat diabetes. However, its effect on pulmonary arterial hypertension (PAH) is unknown. In this study, we investigated its effects on rats with monocrotaline (MCT)-induced PAH and mechanisms on rat pulmonary artery...

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Detalles Bibliográficos
Autores principales: Lee, Mei-Yueh, Tsai, Kun-Bow, Hsu, Jong-Hau, Shin, Shyi-Jang, Wu, Jiunn-Ren, Yeh, Jwu-Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007506/
https://www.ncbi.nlm.nih.gov/pubmed/27581840
http://dx.doi.org/10.1038/srep31788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007506/
https://www.ncbi.nlm.nih.gov/pubmed/27581840
http://dx.doi.org/10.1038/srep31788

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