Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction

Phenotypic modulation of smooth muscle cells is a hallmark of disease. The associated expansion of endoplasmic reticulum (ER) volume remains unexplained. Thrombospondin-4 was recently found to promote ATF6α activation leading to ER expansion. Using bladder outlet obstruction as a paradigm for phenot...

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Detalles Bibliográficos
Autores principales: Krawczyk, Katarzyna K., Ekman, Mari, Rippe, Catarina, Grossi, Mario, Nilsson, Bengt-Olof, Albinsson, Sebastian, Uvelius, Bengt, Swärd, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007532/
https://www.ncbi.nlm.nih.gov/pubmed/27581066
http://dx.doi.org/10.1038/srep32449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007532/
https://www.ncbi.nlm.nih.gov/pubmed/27581066
http://dx.doi.org/10.1038/srep32449

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