Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β

Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1. We recently found that CLC-1 degradation is mediated by cullin 4 ubiquitin ligase complex. It is curren...

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Detalles Bibliográficos
Autores principales: Peng, Yi-Jheng, Huang, Jing-Jia, Wu, Hao-Han, Hsieh, Hsin-Ying, Wu, Chia-Ying, Chen, Shu-Ching, Chen, Tsung-Yu, Tang, Chih-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007535/
https://www.ncbi.nlm.nih.gov/pubmed/27580824
http://dx.doi.org/10.1038/srep32444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007535/
https://www.ncbi.nlm.nih.gov/pubmed/27580824
http://dx.doi.org/10.1038/srep32444

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