The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth

We explore mechanisms that enable cancer cells to tolerate PI3K or Akt inhibitors. Prolonged treatment of breast cancer cells with PI3K or Akt inhibitors leads to increased expression and activation of a kinase termed SGK3 that is related to Akt. Under these conditions, SGK3 is controlled by hVps34...

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Detalles Bibliográficos
Autores principales: Bago, Ruzica, Sommer, Eeva, Castel, Pau, Crafter, Claire, Bailey, Fiona P, Shpiro, Natalia, Baselga, José, Cross, Darren, Eyers, Patrick A, Alessi, Dario R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007552/
https://www.ncbi.nlm.nih.gov/pubmed/27481935
http://dx.doi.org/10.15252/embj.201693929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007552/
https://www.ncbi.nlm.nih.gov/pubmed/27481935
http://dx.doi.org/10.15252/embj.201693929

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