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The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth
We explore mechanisms that enable cancer cells to tolerate PI3K or Akt inhibitors. Prolonged treatment of breast cancer cells with PI3K or Akt inhibitors leads to increased expression and activation of a kinase termed SGK3 that is related to Akt. Under these conditions, SGK3 is controlled by hVps34...
Autores principales: | Bago, Ruzica, Sommer, Eeva, Castel, Pau, Crafter, Claire, Bailey, Fiona P, Shpiro, Natalia, Baselga, José, Cross, Darren, Eyers, Patrick A, Alessi, Dario R |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007552/ https://www.ncbi.nlm.nih.gov/pubmed/27481935 http://dx.doi.org/10.15252/embj.201693929 |
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