Pre-formulation and systematic evaluation of amino acid assisted permeability of insulin across in vitro buccal cell layers

The aim of this work was to investigate alternative safe and effective permeation enhancers for buccal peptide delivery. Basic amino acids improved insulin solubility in water while 200 and 400 μg/mL lysine significantly increased insulin solubility in HBSS. Permeability data showed a significant im...

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Detalles Bibliográficos
Autores principales: Iyire, Affiong, Alayedi, Maryam, Mohammed, Afzal R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007592/
https://www.ncbi.nlm.nih.gov/pubmed/27581177
http://dx.doi.org/10.1038/srep32498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007592/
https://www.ncbi.nlm.nih.gov/pubmed/27581177
http://dx.doi.org/10.1038/srep32498

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