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Pre-formulation and systematic evaluation of amino acid assisted permeability of insulin across in vitro buccal cell layers
The aim of this work was to investigate alternative safe and effective permeation enhancers for buccal peptide delivery. Basic amino acids improved insulin solubility in water while 200 and 400 μg/mL lysine significantly increased insulin solubility in HBSS. Permeability data showed a significant im...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007592/ https://www.ncbi.nlm.nih.gov/pubmed/27581177 http://dx.doi.org/10.1038/srep32498 |