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SPARC expression by cerebral microvascular endothelial cells in vitro and its influence on blood-brain barrier properties

BACKGROUND: SPARC (secreted protein acidic and rich in cysteine) is a nonstructural, cell-matrix modulating protein involved in angiogenesis and endothelial barrier function, yet its potential role in cerebrovascular development, inflammation, and repair in the central nervous system (CNS) remains u...

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Detalles Bibliográficos
Autores principales: Alkabie, Samir, Basivireddy, Jayasree, Zhou, Lixin, Roskams, Jane, Rieckmann, Peter, Quandt, Jacqueline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007716/
https://www.ncbi.nlm.nih.gov/pubmed/27581191
http://dx.doi.org/10.1186/s12974-016-0657-9