Continual reassessment method for dose escalation clinical trials in oncology: a comparison of prior skeleton approaches using AZD3514 data

BACKGROUND: The continual reassessment method (CRM) requires an underlying model of the dose-toxicity relationship (“prior skeleton”) and there is limited guidance of what this should be when little is known about this association. In this manuscript the impact of applying the CRM with different pri...

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Detalles Bibliográficos
Autores principales: James, Gareth D., Symeonides, Stefan N., Marshall, Jayne, Young, Julia, Clack, Glen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007718/
https://www.ncbi.nlm.nih.gov/pubmed/27581751
http://dx.doi.org/10.1186/s12885-016-2702-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007718/
https://www.ncbi.nlm.nih.gov/pubmed/27581751
http://dx.doi.org/10.1186/s12885-016-2702-6

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