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p38-MAPK/MSK1-mediated overexpression of histone H3 serine 10 phosphorylation defines distance-dependent prognostic value of negative resection margin in gastric cancer

BACKGROUND: Alterations in histone modifications are now well known to result in epigenetic heterogeneity in tumor tissues; however, their prognostic value and association with resection margins still remain poorly understood and controversial. Further, histopathologically negative resection margins...

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Detalles Bibliográficos
Autores principales: Khan, Shafqat Ali, Amnekar, Ramchandra, Khade, Bharat, Barreto, Savio George, Ramadwar, Mukta, Shrikhande, Shailesh V., Gupta, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007744/
https://www.ncbi.nlm.nih.gov/pubmed/27588146
http://dx.doi.org/10.1186/s13148-016-0255-9