Anti-cancer effect of pristimerin by inhibition of HIF-1α involves the SPHK-1 pathway in hypoxic prostate cancer cells

BACKGROUND: Hypoxia is a typical character of locally advanced solid tumours. The transcription factor hypoxia-inducible factor 1α (HIF-1α) is the main regulator under the hypoxic environment. HIF-1α regulates various genes to enhance tumour progression, angiogenesis, and metastasis. Sphingosine kin...

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Detalles Bibliográficos
Autores principales: Lee, Seon-Ok, Kim, Joo-Seok, Lee, Myoung-Sun, Lee, Hyo-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007821/
https://www.ncbi.nlm.nih.gov/pubmed/27581969
http://dx.doi.org/10.1186/s12885-016-2730-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007821/
https://www.ncbi.nlm.nih.gov/pubmed/27581969
http://dx.doi.org/10.1186/s12885-016-2730-2

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