Cargando…

Anti-cancer effect of pristimerin by inhibition of HIF-1α involves the SPHK-1 pathway in hypoxic prostate cancer cells

BACKGROUND: Hypoxia is a typical character of locally advanced solid tumours. The transcription factor hypoxia-inducible factor 1α (HIF-1α) is the main regulator under the hypoxic environment. HIF-1α regulates various genes to enhance tumour progression, angiogenesis, and metastasis. Sphingosine kin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Seon-Ok, Kim, Joo-Seok, Lee, Myoung-Sun, Lee, Hyo-Jeong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007821/ https://www.ncbi.nlm.nih.gov/pubmed/27581969 http://dx.doi.org/10.1186/s12885-016-2730-2

Ejemplares similares

Sphingosine Kinase-1 Involves the Inhibitory Action of HIF-1α by Chlorogenic Acid in Hypoxic DU145 Cells
por: Lee, Myoung-Sun, et al.
Publicado: (2017)

SPHK/HIF-1α Signaling Pathway Has a Critical Role in Chrysin-Induced Anticancer Activity in Hypoxia-Induced PC-3 Cells
por: Han, Hengmin, et al.
Publicado: (2022)

Suppression of STAT3 and HIF-1 Alpha Mediates Anti-Angiogenic Activity of Betulinic Acid in Hypoxic PC-3 Prostate Cancer Cells
por: Shin, Jimin, et al.
Publicado: (2011)

HIF2α/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy
por: Kwak, Ji-Hye, et al.
Publicado: (2016)

HIF-1α/Beclin1-Mediated Autophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning
por: Lu, Na, et al.
Publicado: (2018)

KAI1 suppresses HIF-1α and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer
por: Park, Jung-Jin, et al.
Publicado: (2012)

Thymoquinone Selectively Kills Hypoxic Renal Cancer Cells by Suppressing HIF-1α-Mediated Glycolysis
por: Lee, Yoon-Mi, et al.
Publicado: (2019)

Antifungal Activity of Maytenin and Pristimerin
por: Gullo, Fernanda P., et al.
Publicado: (2012)

JNK Contributes to Hif-1α Regulation in Hypoxic Neurons
por: Antoniou, Xanthi, et al.
Publicado: (2009)

HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
por: Lee, Shen-Han, et al.
Publicado: (2021)

Combination of pristimerin and paclitaxel additively induces autophagy in human breast cancer cells via ERK1/2 regulation
por: Lee, Younju, et al.
Publicado: (2018)

Ubiquitin-proteasomal degradation of antiapoptotic survivin facilitates induction of apoptosis in prostate cancer cells by pristimerin
por: LIU, YONG BO, et al.
Publicado: (2014)

Relationship between the expression of CD133, HIF-1α, VEGF and the proliferation and apoptosis in hypoxic human prostate cancer cells
por: Liu, Lingyun, et al.
Publicado: (2017)

Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth
por: Jin, Lu, et al.
Publicado: (2023)

HIF-1α downregulation and apoptosis in hypoxic prostate tumor cells infected with oncolytic Mammalian Orthoreovirus
por: Gupta-Saraf, Pooja, et al.
Publicado: (2014)

SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α
por: Ao, Qilin, et al.
Publicado: (2015)

Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization
por: Bruno, Tiziana, et al.
Publicado: (2017)

Anti-Cancer Effects of Pristimerin and the Mechanisms: A Critical Review
por: Li, Jia-jun, et al.
Publicado: (2019)

Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances
por: Chen, Run-Ze, et al.
Publicado: (2021)

Overexpression of MMP-9 and HIF-1α in Breast Cancer Cells under Hypoxic Conditions
por: Choi, Jae Young, et al.
Publicado: (2011)

IL-33-HIF1α Axis in Hypoxic Pulmonary Hypertension
por: Kumar, Rahul, et al.
Publicado: (2018)

SPHK1 regulates proliferation and survival responses in triple-negative breast cancer
por: Datta, Arpita, et al.
Publicado: (2014)

HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
por: Wang, Pan, et al.
Publicado: (2022)

Hypoxic preconditioning protection is eliminated in HIF-1α knockout mice subjected to neonatal hypoxia-ischemia
por: Sheldon, R. Ann, et al.
Publicado: (2014)

Hypoxic Preconditioning Promotes the Bioactivities of Mesenchymal Stem Cells via the HIF-1α-GRP78-Akt Axis
por: Lee, Jun Hee, et al.
Publicado: (2017)

Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
por: Tarade, Daniel, et al.
Publicado: (2019)

AKT, a Key Transmitter of HIF-1α and AR Signaling Pathways, Has a Critical Role in the Apigetrin-Mediated Anti-Cancer Effects in Prostate Cancer Cells
por: Lee, You-Kyung, et al.
Publicado: (2022)

Pristimerin Causes G1 Arrest, Induces Apoptosis, and Enhances the Chemosensitivity to Gemcitabine in Pancreatic Cancer Cells
por: Wang, Yongwei, et al.
Publicado: (2012)

Strategies To Assess Hypoxic/HIF-1-Active Cancer Cells for the Development of Innovative Radiation Therapy
por: Yeom, Chan Joo, et al.
Publicado: (2011)

Hypoxic Regulation of VEGF, HIF-1(alpha) in Coronary Collaterals Development
por: Sung, Ki Chul, et al.
Publicado: (2005)

Association of NRF2 with HIF-2α-induced cancer stem cell phenotypes in chronic hypoxic condition
por: Hallis, Steffanus Pranoto, et al.
Publicado: (2023)

Overexpression of CD44 Standard Isoform Upregulates HIF-1α Signaling in Hypoxic Breast Cancer Cells
por: Ryu, Dayoung, et al.
Publicado: (2018)

NQO1 inhibits proteasome-mediated degradation of HIF-1α
por: Oh, Eun-Taex, et al.
Publicado: (2016)

Therapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-Diseases
por: Bu, Yanhong, et al.
Publicado: (2021)

Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells
por: Hafizi, Redona, et al.
Publicado: (2022)

PKM2 and HIF-1α regulation in prostate cancer cell lines
por: Hasan, Diya, et al.
Publicado: (2018)

UCA1 Overexpression Promotes Hypoxic Breast Cancer Cell Proliferation and Inhibits Apoptosis via HIF-1α Activation
por: Choudhry, Hani
Publicado: (2021)

HIF-1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions
por: Zhang, Zhan, et al.
Publicado: (2020)

A systematic study of HIF1A cofactors in hypoxic cancer cells
por: Zhang, Yuxiang, et al.
Publicado: (2022)

Hypoxia represses early responses of prostate and renal cancer cells to YM155 independent of HIF-1α and HIF-2α
por: Danielpour, David, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q1k64bd9umacb2udqfg0j0f595