Cargando…

Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth

Stimulating tumor cell senescence and apoptosis are proven methods for therapeutically combating cancer. However, senescence and apoptosis are conventionally viewed as parallel, not sequential, processes. We have discovered that the metastasis-promoting phosphatase, PRL-3, is transcriptionally regul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gari, H H, DeGala, G D, Lucia, M S, Lambert, J R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007826/ https://www.ncbi.nlm.nih.gov/pubmed/27526109 http://dx.doi.org/10.1038/oncsis.2016.50

Ejemplares similares

Genome-wide functional genetic screen with the anticancer agent AMPI-109 identifies PRL-3 as an oncogenic driver in triple-negative breast cancers
por: Gari, Hamid H., et al.
Publicado: (2016)

Phosphatase, pseudo-phosphatase, or both? Understanding PRL oncogenicity
por: Gehring, Kalle, et al.
Publicado: (2020)

Oncogenic function and prognostic significance of protein tyrosine phosphatase PRL-1 in hepatocellular carcinoma
por: Jin, Shaowen, et al.
Publicado: (2014)

Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD–negative acute myeloid leukemia
por: Qu, Shuang, et al.
Publicado: (2014)

Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer
por: Radke, I, et al.
Publicado: (2006)

Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3
por: Rubio, Teresa, et al.
Publicado: (2016)

Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis
por: Bai, Yunpeng, et al.
Publicado: (2016)

PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling
por: Poulet, Mathilde, et al.
Publicado: (2020)

Src-Mediated Phosphorylation of the Tyrosine Phosphatase PRL-3 Is Required for PRL-3 Promotion of Rho Activation, Motility and Invasion
por: Fiordalisi, James J., et al.
Publicado: (2013)

Phosphatase and Pseudo-Phosphatase Functions of Phosphatase of Regenerating Liver 3 (PRL-3) Are Insensitive to Divalent Metals In Vitro
por: Jolly, Jeffery T., et al.
Publicado: (2023)

Expression and Clinical Role of Protein of Regenerating Liver (PRL) Phosphatases in Ovarian Carcinoma
por: Reich, Reuven, et al.
Publicado: (2011)

Metastasis-associated phosphatase PRL-2 regulates tumor cell migration and invasion
por: Wang, Yan, et al.
Publicado: (2011)

The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition
por: Rubio, Teresa, et al.
Publicado: (2021)

Drosophila PRL-1 Is a Growth Inhibitor That Counteracts the Function of the Src Oncogene
por: Pagarigan, Krystle T., et al.
Publicado: (2013)

The Tyrosine Phosphatase PRL Regulates Attachment of Toxoplasma gondii to Host Cells and Is Essential for Virulence
por: Yang, Chunlin, et al.
Publicado: (2022)

Positive Feedback Promotes Oscillations in Negative Feedback Loops
por: Ananthasubramaniam, Bharath, et al.
Publicado: (2014)

Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia
por: Park, Jung Eun, et al.
Publicado: (2013)

Metastatic Phosphatase PRL-3 Induces Ovarian Cancer Stem Cell Sub-population through Phosphatase-Independent Deacetylation Modulations
por: Zhang, Mingming, et al.
Publicado: (2019)

Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma
por: Xing, Xiaofang, et al.
Publicado: (2013)

PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3
por: Zhang, Huizhi, et al.
Publicado: (2017)

The pro-metastasis tyrosine phosphatase, PRL-3 (PTP4A3), is a novel mediator of oncogenic function of BCR-ABL in human chronic myeloid leukemia
por: Zhou, Jianbiao, et al.
Publicado: (2012)

Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3
por: Smith, Caroline N., et al.
Publicado: (2023)

PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
por: Thura, Min, et al.
Publicado: (2019)

Correction: Phosphatase of regenerating liver-3 (PRL-3) is associated with metastasis and poor prognosis in gastric carcinoma
por: Xing, Xiaofang, et al.
Publicado: (2014)

The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells
por: Slørdahl, Tobias S., et al.
Publicado: (2016)

Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration
por: Hjort, Magnus Aassved, et al.
Publicado: (2018)

Mutational Analysis of a Conserved Glutamate Reveals Unique Mechanistic and Structural Features of the Phosphatase PRL-3
por: Hoeger, Birgit, et al.
Publicado: (2017)

Erratum: PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3
por: Zhang, Huizhi, et al.
Publicado: (2017)

PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics
por: Hardy, Serge, et al.
Publicado: (2023)

An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma
por: Drier, Yotam, et al.
Publicado: (2016)

MiR-130a-3p Inhibits PRL Expression and Is Associated With Heat Stress-Induced PRL Reduction
por: Zhang, Haojie, et al.
Publicado: (2020)

Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration
por: Vandsemb, Esten N., et al.
Publicado: (2016)

Cip2a/miR-301a feedback loop promotes cell proliferation and invasion of triple-negative breast cancer
por: Yin, Jiang, et al.
Publicado: (2019)

Author Correction: PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
por: Thura, Min, et al.
Publicado: (2021)

miR-339-5p Increases Radiosensitivity of Lung Cancer Cells by Targeting Phosphatases of Regenerating Liver-1 (PRL-1)
por: Wang, Jia, et al.
Publicado: (2018)

PRL2 serves as a negative regulator in cell adaptation to oxidative stress
por: Du, Xinyue, et al.
Publicado: (2019)

Effect of Disease Progression on the PRL Location in Patients With Bilateral Central Vision Loss
por: Tarita-Nistor, Luminita, et al.
Publicado: (2020)

PRL-3, a Metastasis Associated Tyrosine Phosphatase, Is Involved in FLT3-ITD Signaling and Implicated in Anti-AML Therapy
por: Zhou, Jianbiao, et al.
Publicado: (2011)

An autoregulatory negative feedback loop controls thermomorphogenesis in Arabidopsis
por: Lee, Sanghwa, et al.
Publicado: (2021)

Designing negative feedback loops in enzymatic coacervate droplets
por: Modi, Nisha, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cjgb33fgoljonj3u5b4ekuktc0