A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway

BACKGROUND: Trastuzumab, a humanized antibody targeting HER2, exhibits remarkable therapeutic efficacy against HER2-positive gastric cancer. However, recurrent therapeutic resistance presents revolutionary claims. Warburg effect and AKT signaling pathway was involved in the resistance to trastuzumab...

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Detalles Bibliográficos
Autores principales: Liu, Jing, Pan, Changqie, Guo, Lihong, Wu, Mengwan, Guo, Jing, Peng, Sheng, Wu, Qianying, Zuo, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007850/
https://www.ncbi.nlm.nih.gov/pubmed/27581375
http://dx.doi.org/10.1186/s13045-016-0302-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007850/
https://www.ncbi.nlm.nih.gov/pubmed/27581375
http://dx.doi.org/10.1186/s13045-016-0302-1

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