CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors

Carcinoembryonic antigen T cell bispecific antibody (CEA TCB) is a bispecific antibody used to recognize CEA and CD3e via a novel molecular format (2:1) that induces T cell-mediated killing of CEA over-expressing tumors while sparing primary cells with low CEA expression. CEA TCB treatment inhibits...

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Detalles Bibliográficos
Autores principales: Bacac, Marina, Klein, Christian, Umana, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007959/
https://www.ncbi.nlm.nih.gov/pubmed/27622073
http://dx.doi.org/10.1080/2162402X.2016.1203498
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author Bacac, Marina
Klein, Christian
Umana, Pablo
author_facet Bacac, Marina
Klein, Christian
Umana, Pablo
author_sort Bacac, Marina
collection PubMed
description Carcinoembryonic antigen T cell bispecific antibody (CEA TCB) is a bispecific antibody used to recognize CEA and CD3e via a novel molecular format (2:1) that induces T cell-mediated killing of CEA over-expressing tumors while sparing primary cells with low CEA expression. CEA TCB treatment inhibits tumor growth and generates a highly inflamed tumor microenvironment.
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spelling pubmed-50079592016-09-12 CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors Bacac, Marina Klein, Christian Umana, Pablo Oncoimmunology Author's View Carcinoembryonic antigen T cell bispecific antibody (CEA TCB) is a bispecific antibody used to recognize CEA and CD3e via a novel molecular format (2:1) that induces T cell-mediated killing of CEA over-expressing tumors while sparing primary cells with low CEA expression. CEA TCB treatment inhibits tumor growth and generates a highly inflamed tumor microenvironment. Taylor & Francis 2016-06-24 /pmc/articles/PMC5007959/ /pubmed/27622073 http://dx.doi.org/10.1080/2162402X.2016.1203498 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Author's View
Bacac, Marina
Klein, Christian
Umana, Pablo
CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors
title CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors
title_full CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors
title_fullStr CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors
title_full_unstemmed CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors
title_short CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors
title_sort cea tcb: a novel head-to-tail 2:1 t cell bispecific antibody for treatment of cea-positive solid tumors
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007959/
https://www.ncbi.nlm.nih.gov/pubmed/27622073
http://dx.doi.org/10.1080/2162402X.2016.1203498
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AT umanapablo ceatcbanovelheadtotail21tcellbispecificantibodyfortreatmentofceapositivesolidtumors

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