A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition

DYRK1A is important in neuronal development and function, and its excessive activity is considered a significant pathogenic factor in Down syndrome and Alzheimer's disease. Thus, inhibition of DYRK1A has been suggested to be a new strategy to modify the disease. Very few compounds, however, hav...

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Detalles Bibliográficos
Autores principales: Kim, Hyeongki, Lee, Kyu-Sun, Kim, Ae-Kyeong, Choi, Miri, Choi, Kwangman, Kang, Mingu, Chi, Seung-Wook, Lee, Min-Sung, Lee, Jeong-Soo, Lee, So-Young, Song, Woo-Joo, Yu, Kweon, Cho, Sungchan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007978/
https://www.ncbi.nlm.nih.gov/pubmed/27483355
http://dx.doi.org/10.1242/dmm.025668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007978/
https://www.ncbi.nlm.nih.gov/pubmed/27483355
http://dx.doi.org/10.1242/dmm.025668

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