Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma

Patients with von Hippel–Lindau (VHL) disease harbor a germline mutation in the VHL gene leading to the development of several tumor types including clear cell renal cell carcinoma (ccRCC). In addition, the VHL gene is inactivated in over 90% of sporadic ccRCC cases. ‘Clear cell’ tumors contain larg...

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Detalles Bibliográficos
Autores principales: Noonan, Haley R., Metelo, Ana M., Kamei, Caramai N., Peterson, Randall T., Drummond, Iain A., Iliopoulos, Othon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007981/
https://www.ncbi.nlm.nih.gov/pubmed/27491085
http://dx.doi.org/10.1242/dmm.024380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007981/
https://www.ncbi.nlm.nih.gov/pubmed/27491085
http://dx.doi.org/10.1242/dmm.024380

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