Cargando…

Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma

Patients with von Hippel–Lindau (VHL) disease harbor a germline mutation in the VHL gene leading to the development of several tumor types including clear cell renal cell carcinoma (ccRCC). In addition, the VHL gene is inactivated in over 90% of sporadic ccRCC cases. ‘Clear cell’ tumors contain larg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Noonan, Haley R., Metelo, Ana M., Kamei, Caramai N., Peterson, Randall T., Drummond, Iain A., Iliopoulos, Othon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007981/ https://www.ncbi.nlm.nih.gov/pubmed/27491085 http://dx.doi.org/10.1242/dmm.024380

Ejemplares similares

HIF2a inhibitors for the treatment of VHL disease
por: Metelo, Ana Martins, et al.
Publicado: (2015)

Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish
por: Zhang, Qi, et al.
Publicado: (2012)

Mechanical Stretch and PI3K Signaling Link Cell Migration and Proliferation to Coordinate Epithelial Tubule Morphogenesis in the Zebrafish Pronephros
por: Vasilyev, Aleksandr, et al.
Publicado: (2012)

Wnt signaling mediates new nephron formation during zebrafish kidney regeneration
por: Kamei, Caramai N., et al.
Publicado: (2019)

Laser Ablation of the Zebrafish Pronephros to Study Renal Epithelial Regeneration
por: Johnson, Corbin S., et al.
Publicado: (2011)

A Comparative Analysis of Glomerulus Development in the Pronephros of Medaka and Zebrafish
por: Ichimura, Koichiro, et al.
Publicado: (2012)

The tbx2a/b transcription factors direct pronephros segmentation and corpuscle of Stannius formation in zebrafish
por: Drummond, Bridgette E., et al.
Publicado: (2016)

The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros
por: Wingert, Rebecca A, et al.
Publicado: (2007)

Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros
por: FUKUYO, YAYOI, et al.
Publicado: (2014)

Thiosulfate sulfurtransferase prevents hyperglycemic damage to the zebrafish pronephros in an experimental model for diabetes
por: Al-Dahmani, Zayana M., et al.
Publicado: (2022)

The zebrafish paralog six2b is required for early proximal pronephros morphogenesis
por: Belcher, Beau, et al.
Publicado: (2023)

Understanding the Impact of Belzutifan on Treatment Strategies for Patients with VHL
por: Arevalo, Aileen, et al.
Publicado: (2022)

EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish
por: Barrodia, Praveen, et al.
Publicado: (2018)

Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary
por: Liu, Yulong, et al.
Publicado: (2022)

Yes-Associated Protein (Yap) Is Necessary for Ciliogenesis and Morphogenesis during Pronephros Development in Zebrafish (Danio Rerio)
por: He, Liangliang, et al.
Publicado: (2015)

Iroquois transcription factor irx2a is required for multiciliated and transporter cell fate decisions during zebrafish pronephros development
por: Marra, Amanda N., et al.
Publicado: (2019)

Histone Deacetylases Cooperate with NF-κB to Support the Immediate Migratory Response after Zebrafish Pronephros Injury
por: Zhuang, Mingyue, et al.
Publicado: (2022)

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma
por: Hu, Junhui, et al.
Publicado: (2023)

MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma
por: Bailey, Sean T., et al.
Publicado: (2017)

Expression of Wnt Signaling Components during Xenopus Pronephros Development
por: Zhang, Bo, et al.
Publicado: (2011)

Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors
por: Moore, Lee E., et al.
Publicado: (2011)

Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines
por: Wang, Xuechun, et al.
Publicado: (2022)

Comparative Studies of the Proteome, Glycoproteome, and N-Glycome of Clear Cell Renal Cell Carcinoma Plasma before and after Curative Nephrectomy
por: Gbormittah, Francisca O., et al.
Publicado: (2014)

Characterization of VHL missense mutations in sporadic clear cell renal cell carcinoma: hotspots, affected binding domains, functional impact on pVHL and therapeutic relevance
por: Razafinjatovo, Caroline, et al.
Publicado: (2016)

Amphetamine recapitulates developmental programs in the zebrafish
por: Cadet, Jean Lud
Publicado: (2009)

Xenopus Ssbp2 is required for embryonic pronephros morphogenesis and terminal differentiation
por: Cervino, Ailen S., et al.
Publicado: (2023)

Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer
por: Stewart, Grant D., et al.
Publicado: (2016)

Cytosine 5-hydroxymethylation regulates VHL gene expression in renal clear cell carcinoma
por: Ma, En-Guang, et al.
Publicado: (2017)

Kidney in VHL disease: Early clear cell proliferation occurs in the distal tubular system
por: Al-Gharaibeh, Nayef S., et al.
Publicado: (2022)

Targeting HIF2α Translation with Tempol in VHL-Deficient Clear Cell Renal Cell Carcinoma
por: Sourbier, Carole, et al.
Publicado: (2012)

VHL Dependent Expression of REDD1 and PDK3 Proteins in Clear-cell Renal Cell Carcinoma
por: Ilic, Bojana B, et al.
Publicado: (2018)

Identification and validation of the clinical roles of the VHL-related LncRNAs in clear cell renal cell carcinoma
por: Yang, Wuping, et al.
Publicado: (2021)

Development and validation of a VHL-associated immune prognostic signature for clear cell renal cell carcinoma
por: Zhang, Jin, et al.
Publicado: (2020)

VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma
por: Ganner, Athina, et al.
Publicado: (2021)

Determination of the consequences of VHL mutations on VHL transcripts in renal cell carcinoma
por: TAYLOR, CLAIRE, et al.
Publicado: (2012)

Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations
por: Shen, H.-C. Jennifer, et al.
Publicado: (2009)

Clinicopathologic Significance of VHL Gene Alteration in Clear-Cell Renal Cell Carcinoma: An Updated Meta-Analysis and Review
por: Kim, Hyeong Su, et al.
Publicado: (2018)

VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2
por: Gao, Yao-Hui, et al.
Publicado: (2017)

Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice
por: Harlander, Sabine, et al.
Publicado: (2017)

Consequences of VHL Loss on Global DNA Methylome
por: Robinson, Claire M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_nh8s6kv4jqdhnq75ho4perdol1