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Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin

Parkinson's disease (PD) is characterized by selective loss of dopaminergic neurons in the pars compacta of the substantia nigra and accumulation of ubiquitinated proteins in aggregates called Lewy bodies. Several mutated genes have been found in familial PD patients, including SNCA (α-synuclei...

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Detalles Bibliográficos
Autores principales: Im, Eunju, Yoo, Lang, Hyun, Minju, Shin, Woo Hyun, Chung, Kwang Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008018/
https://www.ncbi.nlm.nih.gov/pubmed/27534820
http://dx.doi.org/10.1098/rsob.160193