LV305, a dendritic cell-targeting integration-deficient ZVex(TM)-based lentiviral vector encoding NY-ESO-1, induces potent anti-tumor immune response

We have engineered an integration-deficient lentiviral vector, LV305, to deliver the tumor antigen NY-ESO-1 to human dendritic cells in vivo through pseudotyping with a modified Sindbis virus envelop protein. Mice immunized once with LV305 developed strong, dose-dependent, multifunctional, and cytot...

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Detalles Bibliográficos
Autores principales: Albershardt, Tina Chang, Campbell, David James, Parsons, Andrea Jean, Slough, Megan Merrill, ter Meulen, Jan, Berglund, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008268/
https://www.ncbi.nlm.nih.gov/pubmed/27626061
http://dx.doi.org/10.1038/mto.2016.10

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008268/
https://www.ncbi.nlm.nih.gov/pubmed/27626061
http://dx.doi.org/10.1038/mto.2016.10

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