The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells

Epigenetic therapies have emerged as promising anticancer approaches, since epigenetic modifications play a major role in tumor initiation and progression. Hydralazine, an approved vasodilator and antihypertensive drug, has been recently shown to act as a DNA methylation inhibitor. Even though hydra...

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Detalles Bibliográficos
Autores principales: Ruiz-Magaña, María J., Martínez-Aguilar, Rocío, Lucendo, Estefanía, Campillo-Davo, Diana, Schulze-Osthoff, Klaus, Ruiz-Ruiz, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008330/
https://www.ncbi.nlm.nih.gov/pubmed/26942461
http://dx.doi.org/10.18632/oncotarget.7871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008330/
https://www.ncbi.nlm.nih.gov/pubmed/26942461
http://dx.doi.org/10.18632/oncotarget.7871

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