Structural characterization of human heparanase reveals insights into substrate recognition

Heparan Sulfate (HS) is a glycosaminoglycan (GAG) which forms a key component of the extracellular matrix (ECM). Breakdown of HS is carried out by heparanase (HPSE), an endo-β-glucuronidase of the glycoside hydrolase (GH)79 family. Overexpression of HPSE is strongly linked to cancer metastases - ref...

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Detalles Bibliográficos
Autores principales: Wu, Liang, Viola, Cristina M., Brzozowski, Andrzej M., Davies, Gideon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008439/
https://www.ncbi.nlm.nih.gov/pubmed/26575439
http://dx.doi.org/10.1038/nsmb.3136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008439/
https://www.ncbi.nlm.nih.gov/pubmed/26575439
http://dx.doi.org/10.1038/nsmb.3136

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