NOTCH1 mediates a switch between two distinct secretomes during senescence

Senescence, a persistent form of cell cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence (OIS) is accompanied by a dynamic fluctuation of NOTCH1 activity, wh...

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Detalles Bibliográficos
Autores principales: Hoare, Matthew, Ito, Yoko, Kang, Tae-Won, Weekes, Michael P., Matheson, Nicholas J., Patten, Daniel A., Shetty, Shishir, Parry, Aled J., Menon, Suraj, Salama, Rafik, Antrobus, Robin, Tomimatsu, Kosuke, Howat, William, Lehner, Paul J., Zender, Lars, Narita, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008465/
https://www.ncbi.nlm.nih.gov/pubmed/27525720
http://dx.doi.org/10.1038/ncb3397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008465/
https://www.ncbi.nlm.nih.gov/pubmed/27525720
http://dx.doi.org/10.1038/ncb3397

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