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Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment
Malignant tumors are caused by uncontrolled proliferation of transformed mutant cells that have lost the ability to maintain tissue integrity. Although a number of causative genetic backgrounds for tumor development have been discovered, the initial steps mutant cells take to escape tissue integrity...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008749/ https://www.ncbi.nlm.nih.gov/pubmed/27584724 http://dx.doi.org/10.1371/journal.pbio.1002537 |