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DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment

Male mammals produce sperm for most of postnatal life and therefore require a robust germ line stem cell system, with precise balance between self-renewal and differentiation. Prior work established doublesex- and mab-3-related transcription factor 1 (Dmrt1) as a conserved transcriptional regulator...

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Detalles Bibliográficos
Autores principales: Zhang, Teng, Oatley, Jon, Bardwell, Vivian J., Zarkower, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008761/
https://www.ncbi.nlm.nih.gov/pubmed/27583450
http://dx.doi.org/10.1371/journal.pgen.1006293