Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model

G Protein Signaling Modulator-3 (GPSM3) is a leukocyte-specific regulator of G protein-coupled receptors (GPCRs), which binds inactivated Gα(i)·GDP subunits and precludes their reassociation with Gβγ subunits. GPSM3 deficiency protects mice from inflammatory arthritis and, in humans, GPSM3 single nu...

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Detalles Bibliográficos
Autores principales: Gall, BJ, Schroer, AB, Gross, JD, Setola, V, Siderovski, DP
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009006/
https://www.ncbi.nlm.nih.gov/pubmed/27307211
http://dx.doi.org/10.1038/gene.2016.26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009006/
https://www.ncbi.nlm.nih.gov/pubmed/27307211
http://dx.doi.org/10.1038/gene.2016.26

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