A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique G(i)-functional Bias

The short chain fatty acid receptor FFA2 is able to stimulate signaling via both G(i)- and G(q)/G(11)-promoted pathways. These pathways are believed to control distinct physiological end points but FFA2 receptor ligands appropriate to test this hypothesis have been lacking. Herein, we characterize A...

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Detalles Bibliográficos
Autores principales: Bolognini, Daniele, Moss, Catherine E., Nilsson, Karolina, Petersson, Annika U., Donnelly, Iona, Sergeev, Eugenia, König, Gabriele M., Kostenis, Evi, Kurowska-Stolarska, Mariola, Miller, Ashley, Dekker, Niek, Tobin, Andrew B., Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009265/
https://www.ncbi.nlm.nih.gov/pubmed/27385588
http://dx.doi.org/10.1074/jbc.M116.736157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009265/
https://www.ncbi.nlm.nih.gov/pubmed/27385588
http://dx.doi.org/10.1074/jbc.M116.736157

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