Mapping the Effect of Gly Mutations in Collagen on α2β1 Integrin Binding

The replacement of one Gly in the essential repeating tripeptide sequence of the type I collagen triple helix results in the dominant hereditary bone disorder osteogenesis imperfecta. The mechanism leading to pathology likely involves misfolding and autophagy, although it has been hypothesized that...

Descripción completa

Detalles Bibliográficos
Autores principales: Yigit, Sezin, Yu, Hongtao, An, Bo, Hamaia, Samir, Farndale, Richard W., Kaplan, David L., Lin, Yu-Shan, Brodsky, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Glycobiology and Extracellular Matrices
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009287/
https://www.ncbi.nlm.nih.gov/pubmed/27432884
http://dx.doi.org/10.1074/jbc.M116.726182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009287/
https://www.ncbi.nlm.nih.gov/pubmed/27432884
http://dx.doi.org/10.1074/jbc.M116.726182

Ejemplares similares