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Mapping the Effect of Gly Mutations in Collagen on α2β1 Integrin Binding

The replacement of one Gly in the essential repeating tripeptide sequence of the type I collagen triple helix results in the dominant hereditary bone disorder osteogenesis imperfecta. The mechanism leading to pathology likely involves misfolding and autophagy, although it has been hypothesized that...

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Detalles Bibliográficos
Autores principales:	Yigit, Sezin, Yu, Hongtao, An, Bo, Hamaia, Samir, Farndale, Richard W., Kaplan, David L., Lin, Yu-Shan, Brodsky, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Glycobiology and Extracellular Matrices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009287/ https://www.ncbi.nlm.nih.gov/pubmed/27432884 http://dx.doi.org/10.1074/jbc.M116.726182

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