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Identification and functional characterization of the miRNA-gene regulatory network in chronic myeloid leukemia lineage negative cells

Chronic myeloid leukemia (CML) is maintained by leukemic stem cells (LSCs) which are resistant to the existing TKI therapy. Hence a better understanding of the CML LSCs is necessary to eradicate these cells and achieve complete cure. Using the miRNA-gene interaction networks from the CML lin(−) cell...

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Detalles Bibliográficos
Autores principales: Agatheeswaran, S., Pattnayak, N. C., Chakraborty, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009428/
https://www.ncbi.nlm.nih.gov/pubmed/27586591
http://dx.doi.org/10.1038/srep32493