The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η

Several important anti-tumor agents form DNA interstrand crosslinks (ICLs), but their clinical efficiency is counteracted by multiple complex DNA repair pathways. All of these pathways require unhooking of the ICL from one strand of a DNA duplex by nucleases, followed by bypass of the unhooked ICL b...

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Detalles Bibliográficos
Autores principales: Roy, Upasana, Mukherjee, Shivam, Sharma, Anjali, Frank, Ekaterina G., Schärer, Orlando D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009737/
https://www.ncbi.nlm.nih.gov/pubmed/27257072
http://dx.doi.org/10.1093/nar/gkw485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009737/
https://www.ncbi.nlm.nih.gov/pubmed/27257072
http://dx.doi.org/10.1093/nar/gkw485

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