An increase in negative supercoiling in bacteria reveals topology-reacting gene clusters and a homeostatic response mediated by the DNA topoisomerase I gene

We studied the transcriptional response to an increase in DNA supercoiling in Streptococcus pneumoniae by using seconeolitsine, a new topoisomerase I inhibitor. A homeostatic response allowing recovery of supercoiling was observed in cells treated with subinhibitory seconeolitsine concentrations. Su...

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Detalles Bibliográficos
Autores principales: Ferrándiz, María-José, Martín-Galiano, Antonio J., Arnanz, Cristina, Camacho-Soguero, Isabel, Tirado-Vélez, José-Manuel, de la Campa, Adela G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009749/
https://www.ncbi.nlm.nih.gov/pubmed/27378778
http://dx.doi.org/10.1093/nar/gkw602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009749/
https://www.ncbi.nlm.nih.gov/pubmed/27378778
http://dx.doi.org/10.1093/nar/gkw602

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