Post-ExSELEX stabilization of an unnatural-base DNA aptamer targeting VEGF(165) toward pharmaceutical applications

A new technology, genetic alphabet expansion using artificial bases (unnatural bases), has created high-affinity DNA ligands (aptamers) that specifically bind to target proteins by ExSELEX (genetic alphabet Expansion for Systematic Evolution of Ligands by EXponential enrichment). We recently found t...

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Detalles Bibliográficos
Autores principales: Kimoto, Michiko, Nakamura, Mana, Hirao, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009754/
https://www.ncbi.nlm.nih.gov/pubmed/27387284
http://dx.doi.org/10.1093/nar/gkw619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009754/
https://www.ncbi.nlm.nih.gov/pubmed/27387284
http://dx.doi.org/10.1093/nar/gkw619

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