AMP‐activated protein kinase inhibits K(v)1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation

KEY POINTS: Progression of hypoxic pulmonary hypertension is thought to be due, in part, to suppression of voltage‐gated potassium channels (K(v)) in pulmonary arterial smooth muscle by hypoxia, although the precise molecular mechanisms have been unclear. AMP‐activated protein kinase (AMPK) has been...

Descripción completa

Detalles Bibliográficos
Autores principales: Moral‐Sanz, Javier, Mahmoud, Amira D., Ross, Fiona A., Eldstrom, Jodene, Fedida, David, Hardie, D. Grahame, Evans, A. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Cardiovascular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009768/
https://www.ncbi.nlm.nih.gov/pubmed/27062501
http://dx.doi.org/10.1113/JP272032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009768/
https://www.ncbi.nlm.nih.gov/pubmed/27062501
http://dx.doi.org/10.1113/JP272032

Ejemplares similares