TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

Immunotherapeutic approaches are currently the most advanced treatments for Alzheimer's disease (AD). Antibodies against amyloid β‐peptide (Aβ) bind to amyloid plaques and induce their clearance by microglia via Fc receptor‐mediated phagocytosis. Dysfunctions of microglia may play a pivotal rol...

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Detalles Bibliográficos
Autores principales: Xiang, Xianyuan, Werner, Georg, Bohrmann, Bernd, Liesz, Arthur, Mazaheri, Fargol, Capell, Anja, Feederle, Regina, Knuesel, Irene, Kleinberger, Gernot, Haass, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009806/
https://www.ncbi.nlm.nih.gov/pubmed/27402340
http://dx.doi.org/10.15252/emmm.201606370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009806/
https://www.ncbi.nlm.nih.gov/pubmed/27402340
http://dx.doi.org/10.15252/emmm.201606370

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