Modeling the functional state of the reverse transcriptase of hepatitis B virus and its application to probing drug-protein interaction

BACKGROUND: Herein, the predicted atomic structures of five representative sequence variants of the reverse transcriptase protein (RT) of hepatitis B virus (HBV), sampled from patients with rapid or slow response to tenofovir disoproxil fumarate (TDF) treatment, have been examined to identify struct...

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Autores principales: Xu, Xiaojun, Thai, Hong, Kitrinos, Kathryn M., Xia, Guoliang, Gaggar, Anuj, Paulson, Matthew, Ganova-Raeva, Lilia, Khudyakov, Yury, Lara, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009823/
https://www.ncbi.nlm.nih.gov/pubmed/27587008
http://dx.doi.org/10.1186/s12859-016-1116-4

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