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Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4(+) T cells but no increase in avidity for Ag85A

There is a need to improve the efficacy of Bacille Calmette-Guérin (BCG) vaccination against tuberculosis in humans and cattle. Previously, we found boosting BCG-primed cows with recombinant human type 5 adenovirus expressing antigen 85A (Ad5-85A) increased protection against Mycobacterium bovis inf...

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Detalles Bibliográficos
Autores principales:	Metcalfe, Hannah J., Steinbach, Sabine, Jones, Gareth J., Connelley, Tim, Morrison, W. Ivan, Vordermeier, Martin, Villarreal-Ramos, Bernardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009893/ https://www.ncbi.nlm.nih.gov/pubmed/27498622 http://dx.doi.org/10.1016/j.vaccine.2016.07.055

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